Our Carboxygenator in the spotlight!

Ever wondered how our carboxygenator precisely works within the SCINUS bioreactor NG?

We get that question more often, so today weโ€™re excited to share the science behind it, step by step:

๐—ฃ๐—ฟ๐—ฒ๐—ฐ๐—ถ๐˜€๐—ฒ ๐—š๐—ฎ๐˜€ ๐—–๐—ผ๐—ป๐˜๐—ฟ๐—ผ๐—น: The carboxygenator is a patented oxygenation system thatโ€™s all about maintaining the ideal gas environment for your cell culture.

๐—œ๐—ป๐˜๐—ฒ๐—ด๐—ฟ๐—ฎ๐˜๐—ฒ๐—ฑ ๐—ฆ๐—ฒ๐—ป๐˜€๐—ผ๐—ฟ๐˜€: Oxygen and pH levels are continuously monitored by advanced sensors within the SCINUS culture bag. This real-time data is crucial for maintaining optimal conditions.

๐——๐—ฎ๐˜๐—ฎ ๐—ง๐—ฟ๐—ฎ๐—ป๐˜€๐—บ๐—ถ๐˜€๐˜€๐—ถ๐—ผ๐—ป: As we continue in the process, this data is transmitted to the controller software of the SCINUS cabinet through transmitters built into the rocking expansion platform.

๐—”๐˜‚๐˜๐—ผ๐—บ๐—ฎ๐˜๐—ฒ๐—ฑ ๐—–๐—ผ๐—ป๐˜๐—ฟ๐—ผ๐—น: Our controller software takes the wheel from here. It ensures that the pre-defined culture environment is maintained by controlling the addition of gases, thanks to the data received.

๐—š๐—ฎ๐˜€ ๐—œ๐—ป๐˜๐—ฟ๐—ผ๐—ฑ๐˜‚๐—ฐ๐˜๐—ถ๐—ผ๐—ป: The addition of gases takes place through gas-permeable tubing in the perfusion loop. This crucial step ensures a seamless and precise process for maintaining the optimal gas environment within the culture bag.

๐—–๐—ผ๐—ป๐˜๐—ถ๐—ป๐˜‚๐—ผ๐˜‚๐˜€ ๐—™๐—ฒ๐—ฒ๐—ฑ๐—ฏ๐—ฎ๐—ฐ๐—ธ-๐—Ÿ๐—ผ๐—ผ๐—ฝ: A continuous feedback loop between the culture bag and the carboxygenator guarantees that setpoints are maintained within minimal bandwidths.

๐—ก๐—ผ ๐—›๐—ฒ๐—ฎ๐—ฑ๐˜€๐—ฝ๐—ฎ๐—ฐ๐—ฒ ๐—ฅ๐—ฒ๐—พ๐˜‚๐—ถ๐—ฟ๐—ฒ๐—ฑ: With our carboxygenator, we can provide your cells with the oxygen they need without the use of a headspace, resulting in a homogenized culture.

๐— ๐—ถ๐—ป๐—ถ๐—บ๐—ถ๐˜‡๐—ฒ๐—ฑ ๐—ฆ๐—ต๐—ฒ๐—ฎ๐—ฟ: Whatโ€™s more, this process minimizes any additional shear on your cells as there is no air-liquid interface during the rocking process.

 

At SCINUS, weโ€™re proud to deliver innovation that empowers your research and cell culture experiments. If youโ€™re as excited about this as we are, letโ€™s keep the conversation going. Reach out, and letโ€™s explore the possibilities together!

A continuous feedback loop between the culture bag and the carboxygenator guarantees that oxygen and pH setpoints are maintained within minimal bandwidths.