Flexible Cell Expansion Applications for Adherent and Suspension Cultures with Osilaris™
Osilaris™ is a flexible, automated bioreactor platform supporting a wide range of clinical grade cell expansion workflows.
Using two types of expandable culture bags, the system enables scalable, closed-system expansion across multiple cell types, including MSC, MSC-EV, HEK,
T-cells (CAR-T, TCR-T, TIL), and iPSC among others, making Osilaris™ suitable for diverse cell therapy and regenerative medicine applications .
Mesenchymal Stromal Cells
Scale MSC expansion in a closed, controlled culture environment. Osilaris™ uses microcarriers and an expandable culture volume to support growth from low starting cell numbers to clinically relevant yields. Integrated pH and dissolved oxygen control, including hypoxic conditions, supports MSC expansion and MSC-derived extracellular vesicle (MSC-EV) production. The automated workflow reduces manual handling and supports process development and scale-up towards GMP manufacturing.
Immune Cells
Bring T-cell processing and expansion together in a closed, controlled platform. Osilaris™ combines an expandable culture volume with integrated pH and dissolved oxygen control to support T-cell and CAR-T workflows. Options for in-bag selection, activation, transduction and media exchange reduce transfers and manual handling. The platform has also been used to culture NK cells and tumour-infiltrating lymphocytes (TILs).
Organoids
Scale organoid expansion in a controlled, dynamic culture environment. Osilaris™ combines adjustable agitation with integrated pH and dissolved oxygen control to support conditions tailored to your organoid culture. Demonstrated expansion of intrahepatic cholangiocyte organoids highlights the platform’s potential for organoid research and the development of regenerative medicine applications.
Induced Pluripotent Stem Cells (iPSCs)
Scale iPSC expansion from static culture to suspension-based aggregates (spheroids). Osilaris™ combines adjustable agitation with integrated pH and dissolved oxygen control to support aggregate formation and growth in a controlled culture environment. The platform supports iPSC process development and scale-up, providing a starting point for downstream differentiation workflows.