Product Brochure
Scinus
The SCINUS Cell Expansion system is a closed bioreactor system for the controlled cultivation of cells, supporting R&D as well as GMP processes. Combined with either the single-use Adherent or Suspension Bag it provides a scalable system for large-fold expansion. The temperature-controlled hardware enclosure houses the Single-use Bags on a unique rocking platform that provides an optimally homogenized culture environment with minimal shear stresses. The platform enables true s caling in culture volume, thanks to a unique roller/clamp system, allowing culture from minimal to clinically relevant amounts in one system. The system operates stand-alone with a touchscreen interface, and is compatible with industry-standard controller software for process control, monitoring and data acquisition.
- Temperature-controlled hardware enclosure for both adherent and suspension cell culture.
- In combination with Scinus® single-use bioreactor Bags, offers unique volume scaling.
- Accurately controlled culture environment through temperature, oxygen and pH control.
- Lower shear stresses than traditional impeller-based bioreactors.
- Compatible with industry-standard Supervisory Control and Data Acquisition (SCADA) software, allowing processes to comply with CFR Part 11 or Eudralex Annex 11.
Adherent Bag
The Single use Adherent Bag is used in combination with SCINUS Cell Expansion system to provide a volume-scalable culture environment for the cultivation of adherent cell types, such as mesenchymal stromal cells. The bag comprises a cell cultivation container with an expandable volume and associated tubing. The unique volume scaling allows an increasing volume, starting at 100 mL up to 1.4 L. Combined with microcarriers, the available surface area can be gradually increased to a total area of at least 35,000 cm2. Integrated sensor technology measures oxygen, pH and biomass at the site of culture. The versatile tubing set with weldable tubing makes it easy to add medium, remove waste or take a representative sample of cells growing in the system (as part of R&D or QC procedure during GMP process), all while maintaining a closed workflow. Compatible with Scinus single-use bottles.
- Sterile, closed Single-use Bag and tubing set for use with the SCINUS Cell Expansion system.
- Integrated oxygen, pH and biomass sensor.
- Ability to sample cells or only medium at any point during you culture process.
- Weldable tubing ensures a closed workflow.
- Complete quality documentation available to support GMP process registration.
Suspension Bag
- Sterile, closed Single-use Bag and tubing set for use with the SCINUS Cell Expansion system.
- Integrated oxygen, pH and biomass sensor.
- Ability to sample cells or only medium at any point during you culture process.
- Weldable tubing ensures a closed workflow.
Single-use Bottles
- Sterile bottles for addition or removal of medium (components).
- Fitted with weldable tubing, maintain a closed workflow.
- Special microcarrier preparation bottle available for use with the Adherent Bag.
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SCINUS Cell Expansion provides an innovative, controlled and cost-effective solution to automate cell culture processes.